Overview

NCI Definition: An aggressive, high grade adenocarcinoma that arises from the salivary glands. It usually affects elderly males and presents as a rapidly enlarging mass. It metastasizes to regional lymph nodes and distant anatomic sites. [1]

Salivary duct carcinomas most frequently harbor alterations in TP53, ERBB2, PIK3CA, NF1, and HRAS [2].

Most Commonly Altered Genes in Salivary Duct Carcinoma

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 c.142-c.212 Missense, TP53 c.1-c.137 Missense, and TP53 Missense are the most common alterations in salivary duct carcinoma [2].

Top Alterations in Salivary Duct Carcinoma

Significant Genes in Salivary Duct Carcinoma

ERBB2 +

Disease Details

Synonyms
Carcinoma of Salivary Duct, Carcinoma of the Salivary Duct, High Grade Salivary Duct Carcinoma
Parent(s)
Salivary Gland Adenocarcinoma
OncoTree Name
Salivary Duct Carcinoma
OncoTree Code
SDCA

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.