Overview

NCI Definition: A carcinoma of the salivary gland characterized by serous acinar cell differentiation. The vast majority of cases occur in the parotid gland. It usually presents as a slowly enlarging mass. A minority of patients experience pain. It may recur or metastasize. Multiple recurrences and metastasis to cervical lymph nodes are usually associated with a poor prognosis. [1]

Salivary gland acinic cell carcinomas most frequently harbor alterations in CDKN2A, CDKN2B, SETD2, PIK3CA, and FBXW7 [2].

CDKN2A Loss, CDKN2B Loss, SETD2 Mutation, PIK3CA Mutation, and TP53 c.217-c.1178 Missense are the most common alterations in salivary gland acinic cell carcinoma [2].

Significant Genes in Salivary Gland Acinic Cell Carcinoma

Disease Details

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.