Overview

NCI Definition: A carcinoma of the salivary gland characterized by serous acinar cell differentiation. The vast majority of cases occur in the parotid gland. It usually presents as a slowly enlarging mass. A minority of patients experience pain. It may recur or metastasize. Multiple recurrences and metastasis to cervical lymph nodes are usually associated with a poor prognosis. [1]

Salivary gland acinic cell carcinomas most frequently harbor alterations in CDKN2A, CDKN2B, SETD2, PIK3CA, and FBXW7 [2].

Most Commonly Altered Genes in Salivary Gland Acinic Cell Carcinoma

CDKN2A Loss, CDKN2A Mutation, SETD2 Mutation, PIK3CA Mutation (somatic), and PIK3CA Mutation are the most common alterations in salivary gland acinic cell carcinoma [2].

Top Alterations in Salivary Gland Acinic Cell Carcinoma

Significant Genes in Salivary Gland Acinic Cell Carcinoma

ERBB2 +

Disease Details

Synonyms
Acinic Cell Tumor of Salivary Gland, Acinic Cell Tumor of the Salivary Gland, Salivary Gland Acinic Cell Tumor, Salivary Gland Acinic Cell Neoplasm, Acinic Cell Carcinoma of Salivary Gland, Acinic Cell Carcinoma of the Salivary Gland, Acinic Cell Neoplasm of Salivary Gland, Acinic Cell Neoplasm of the Salivary Gland, Salivary Gland Acinic Cell Cancer
Parent(s)
Salivary Gland Adenocarcinoma
OncoTree Name
Acinic Cell Carcinoma
OncoTree Code
ACCC

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.