Overview

NCI Definition: An adenocarcinoma arising from the salivary gland. It includes the salivary gland polymorphous low grade adenocarcinoma, salivary gland oncocytic carcinoma, salivary gland mucinous adenocarcinoma, salivary gland low grade cribriform cystadenocarcinoma, salivary gland cystadenocarcinoma, salivary gland basal cell adenocarcinoma, salivary gland acinic cell carcinoma, salivary duct carcinoma, and salivary gland adenocarcinoma not otherwise specified. [1]

Salivary gland adenocarcinomas most frequently harbor alterations in TP53, ERBB2, CDKN2A, PIK3CA, and ETV6 [2].

Most Commonly Altered Genes in Salivary Gland Adenocarcinoma

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 c.142-c.212 Missense, TP53 c.1-c.137 Missense, and TP53 Missense are the most common alterations in salivary gland adenocarcinoma [2].

Top Alterations in Salivary Gland Adenocarcinoma

Significant Genes in Salivary Gland Adenocarcinoma

ERBB2 +

Disease Details

Synonyms
Adenocarcinoma of the Salivary Gland, Adenocarcinoma of Salivary Gland
Parent(s)
Salivary Gland Carcinoma
Children
Mammary Analog Secretory Carcinoma of Salivary Gland, Salivary Duct Carcinoma, and Salivary Gland Acinic Cell Carcinoma
OncoTree Name
Salivary Adenocarcinoma
OncoTree Code
SAAD

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.