Salivary Gland Adenocarcinoma
Associated Genetic Biomarkers
NCI Definition: An adenocarcinoma arising from the salivary gland. It includes the salivary gland polymorphous low grade adenocarcinoma, salivary gland oncocytic carcinoma, salivary gland mucinous adenocarcinoma, salivary gland low grade cribriform cystadenocarcinoma, salivary gland cystadenocarcinoma, salivary gland basal cell adenocarcinoma, salivary gland acinic cell carcinoma, salivary duct carcinoma, and salivary gland adenocarcinoma not otherwise specified. 
Salivary gland adenocarcinomas most frequently harbor alterations in TP53, ERBB2, CDKN2A, PIK3CA, and ETV6 .
TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 c.142-c.212 Missense, TP53 c.1-c.137 Missense, and TP53 Missense are the most common alterations in salivary gland adenocarcinoma .
There is 1 clinical trial for salivary gland adenocarcinoma, of which 1 is open and 0 are completed or closed. Of the trial that contains salivary gland adenocarcinoma as an inclusion criterion, 1 is phase 2 (1 open).
ERBB2 is the most frequent gene inclusion criterion for salivary gland adenocarcinoma clinical trials .
Nanoparticle-based paclitaxel suspension and trastuzumab are the most common interventions in salivary gland adenocarcinoma clinical trials.
Significant Genes in Salivary Gland Adenocarcinoma
ERBB2 is mutated in 17.01% of salivary gland adenocarcinoma patients .
ERBB2 is an inclusion eligibility criterion in 1 clinical trial for salivary gland adenocarcinoma, of which 1 is open and 0 are closed. Of the trial that contains ERBB2 status and salivary gland adenocarcinoma as inclusion criteria, 1 is phase 2 (1 open) .
Nanoparticle-based paclitaxel suspension and trastuzumab are the most frequent therapies in salivary gland adenocarcinoma trials with ERBB2 mutations as inclusion criteria .
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.