Overview

NCI Definition: A carcinoma that arises from the major or minor salivary glands. Representative examples include carcinoma ex pleomorphic adenoma, adenocarcinoma, adenoid cystic carcinoma, and mucoepidermoid carcinoma. [1]

Salivary gland carcinomas most frequently harbor alterations in TP53, NOTCH1, PIK3CA, CDKN2A, and ERBB2 [2].

Most Commonly Altered Genes in Salivary Gland Carcinoma

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, PIK3CA Mutation, and NOTCH1 Mutation are the most common alterations in salivary gland carcinoma [2].

Top Alterations in Salivary Gland Carcinoma

Significant Genes in Salivary Gland Carcinoma

ERBB2 +

MLH1 +

MLH3 +

MSH2 +

MSH3 +

MSH6 +

PMS1 +

PMS2 +

Disease Details

Synonyms
Carcinoma of the Salivary Gland, Carcinoma of Salivary Gland, Salivary gland carcinoma (NOS)
Parent(s)
Malignant Salivary Gland Neoplasm
Children
Salivary Gland Myoepithelial Carcinoma, Salivary Gland Mucoepidermoid Carcinoma, Salivary Gland Adenoid Cystic Carcinoma, Salivary Gland Adenocarcinoma, Salivary Gland Small Cell Carcinoma, Salivary Carcinoma, NOS, Salivary Gland Epithelial-Myoepithelial Carcinoma, Salivary Gland Large Cell Carcinoma, Salivary Gland Carcinoma ex Pleomorphic Adenoma, and Salivary Gland Squamous Cell Carcinoma
OncoTree Name
Salivary Carcinoma
OncoTree Code
SACA

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.