Overview

NCI Definition: A carcinoma that arises from the salivary glands. It is the most common primary carcinoma of the salivary glands and usually presents as a firm and painless mass. It is characterized by the presence of epidermoid cells, mucus producing cells, and cells of intermediate type. The majority of cases have a favorable outcome. [1]

Salivary gland mucoepidermoid carcinomas most frequently harbor alterations in TP53, CDKN2A, PIK3CA, RECQL4, and HRAS [2].

Most Commonly Altered Genes in Salivary Gland Mucoepidermoid Carcinoma

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 c.142-c.212 Missense, TP53 c.1-c.137 Missense, and TP53 Missense are the most common alterations in salivary gland mucoepidermoid carcinoma [2].

Top Alterations in Salivary Gland Mucoepidermoid Carcinoma

Significant Genes in Salivary Gland Mucoepidermoid Carcinoma

ERBB2 +

Disease Details

Synonyms
Mucoepidermoid Carcinoma of the Salivary Gland, Mucoepidermoid Carcinoma of Salivary Gland
Parent(s)
Salivary Gland Carcinoma
OncoTree Name
Mucoepidermoid Carcinoma
OncoTree Code
MUCC

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.