NCI Definition: A malignant epithelial neoplasm characterized by the presence of spindle cells and anaplastic morphologic features. Giant cells and a sarcomatous component may also be present. 
Sarcomatoid carcinomas most frequently harbor alterations in TP53, KRAS, CDKN2A, MET, and CDKN2B .
TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, KRAS Mutation, and KRAS Exon 2 Mutation are the most common alterations in sarcomatoid carcinoma .
There is 1 clinical trial for sarcomatoid carcinoma, of which 1 is open and 0 are completed or closed. Of the trial that contains sarcomatoid carcinoma as an inclusion criterion, 1 is phase 3 (1 open).
Atezolizumab, cabozantinib, and sorafenib are the most common interventions in sarcomatoid carcinoma clinical trials.
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.