Overview

NCI Definition: A malignant epithelial neoplasm characterized by the presence of spindle cells and anaplastic morphologic features. Giant cells and a sarcomatous component may also be present. [1]

Significant Genes in Sarcomatoid Carcinoma

ARID1A +

KDM6A +

KMT2C +

KMT2D +

SMARCA2 +

SMARCA4 +

SMARCB1 +

SS18 +

SSX1 +

SSX2 +

SSX2B +

SSX4 +

Disease Details

Synonyms
CARCINOMA, SPINDLE CELL, MALIGNANT, Pseudosarcomatous Carcinoma, Unknown primary sarcomatoid carcinoma, Spindle Cell Carcinoma
Parent(s)
Carcinoma
Children
Sarcomatoid Transitional Cell Carcinoma, Sarcomatoid Squamous Cell Carcinoma, Sarcomatoid Renal Cell Carcinoma, Laryngeal Squamous Cell Carcinoma, Spindle Cell Variant, Rectal Sarcomatoid Carcinoma, Lung Sarcomatoid Carcinoma, and Thymic Sarcomatoid Carcinoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.