NCI Definition: A malignant epithelial neoplasm characterized by the presence of spindle cells and anaplastic morphologic features. Giant cells and a sarcomatous component may also be present. [1]

Sarcomatoid carcinomas most frequently harbor alterations in TP53, KRAS, CDKN2A, MET, and CDKN2B [2].

Most Commonly Altered Genes in Sarcomatoid Carcinoma

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, KRAS Mutation, and KRAS Exon 2 Mutation are the most common alterations in sarcomatoid carcinoma [2].

Top Alterations in Sarcomatoid Carcinoma

Disease Details

Spindle Cell Carcinoma, CARCINOMA, SPINDLE CELL, MALIGNANT, Pseudosarcomatous Carcinoma
Sarcomatoid Transitional Cell Carcinoma, Lung Sarcomatoid Carcinoma, Sarcomatoid Squamous Cell Carcinoma, Rectal Sarcomatoid Carcinoma, Thymic Sarcomatoid Carcinoma, and Infiltrating Bladder Urothelial Carcinoma Sarcomatoid Variant


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.