Overview

NCI Definition: A high grade carcinoma of the kidney. It is not a distinct clinicopathological entity and includes a diverse group of renal cell carcinomas which have been transformed from a lower to a higher grade. [1]

Sarcomatoid renal cell carcinomas most frequently harbor alterations in TP53 and VHL [2].

Most Commonly Altered Genes in Sarcomatoid Renal Cell Carcinoma

VHL Mutation and TP53 Mutation are the most common alterations in sarcomatoid renal cell carcinoma [2].

Top Alterations in Sarcomatoid Renal Cell Carcinoma

Significant Genes in Sarcomatoid Renal Cell Carcinoma

SDHB +

TFE3 +

TSC1 +

Disease Details

Synonyms
RCC w/ sarcomatoid features, Renal cell carcinoma with sarcomatoid features
Parent(s)
Renal Cell Carcinoma
OncoTree Name
Sarcomatoid Renal Cell Carcinoma
OncoTree Code
SRCC

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.