Overview

NCI Definition: A poorly differentiated transitional cell carcinoma characterized by the presence of malignant cells with spindle cell morphologic features. [1]

Sarcomatoid transitional cell carcinomas most frequently harbor alterations in TP53, CDKN2A, KRAS, KMT2D, and KDM6A [2].

Most Commonly Altered Genes in Sarcomatoid Transitional Cell Carcinoma

TP53 c.217-c.1178 Missense, TP53 Mutation, TP53 Missense, TP53 Exon 7 Mutation, and TP53 Codon 245 Missense are the most common alterations in sarcomatoid transitional cell carcinoma [2].

Top Alterations in Sarcomatoid Transitional Cell Carcinoma

Disease Details

Synonyms
Transitional Cell Spindle Cell Carcinoma, Transitional Spindle Cell Carcinoma
Parent(s)
Transitional Cell Carcinoma
Children
Infiltrating Bladder Urothelial Carcinoma Sarcomatoid Variant and Infiltrating Renal Pelvis Urothelial Carcinoma, Sarcomatoid Variant

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.