Associated Genetic Biomarkers

Overview

NCI Definition: An acute myeloid leukemia secondary to a myelodysplastic syndrome or therapy-related. (WHO, 2001) [1]

Secondary acute myeloid leukemias most frequently harbor alterations in TP53, DNMT3A, TET2, ASXL1, and SRSF2 [2].

Most Commonly Altered Genes in Secondary Acute Myeloid Leukemia

TP53 Mutation, TP53 Missense, TP53 c.217-c.1178 Missense, DNMT3A Mutation, and TET2fs are the most common alterations in secondary acute myeloid leukemia [2].

Top Alterations in Secondary Acute Myeloid Leukemia

Significant Genes in Secondary Acute Myeloid Leukemia

ABL1 +

ABL2 +

AFF1 +

ASXL1 +

BCOR +

BCR +

CBFB +

CBL +

CEBPA +

CREBBP +

CRLF2 +

DEK +

ELL +

EPOR +

ETV6 +

EZH2 +

FGFR1 +

FGFR2 +

FGFR3 +

FGFR4 +

FLT3 +

HIP1 +

HRAS +

IDH1 +

IDH2 +

IL7R +

JAK1 +

JAK2 +

JAK3 +

KIT +

KMT2A +

KRAS +

LYN +

MECOM +

MLF1 +

MLLT1 +

MLLT10 +

MLLT3 +

MLLT4 +

MYH11 +

NF1 +

NPM1 +

NRAS +

NRIP3 +

NTRK1 +

NTRK2 +

NTRK3 +

NUP214 +

PBX1 +

PDGFRA +

PDGFRB +

PRDM16 +

PTPN11 +

RIT1 +

RPN1 +

RUNX1 +

RUNX1T1 +

SF3B1 +

SH2B3 +

SRSF2 +

STAG2 +

TCF3 +

TP53 +

TYK2 +

U2AF1 +

ZRSR2 +

Disease Details

Synonyms
Secondary AGL, Secondary Acute Myeloid Leukemia (AML), Secondary Acute Granulocytic Leukemia, Secondary Acute Myelocytic Leukemia, Secondary AML, Secondary Acute Myelogenous Leukemia, Secondary Acute Myeloblastic Leukemia
Parent(s)
Secondary Malignant Neoplasm
Children
Acute Myeloid Leukemia Arising from Previous Myelodysplastic Syndrome and Therapy-Related Acute Myeloid Leukemia

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.