Diseases /
Secondary Acute Myeloid Leukemia
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Associated Genetic Biomarkers
Overview
NCI Definition: An acute myeloid leukemia secondary to a myelodysplastic syndrome or therapy-related. (WHO, 2001) [1]
Secondary acute myeloid leukemias most frequently harbor alterations in TP53, DNMT3A, TET2, ASXL1, and SRSF2 [2].
TP53 Mutation, TP53 Missense, TP53 c.217-c.1178 Missense, DNMT3A Mutation, and TET2fs are the most common alterations in secondary acute myeloid leukemia [2].
Clinical Trials
Significant Genes in Secondary Acute Myeloid Leukemia
Disease Details
References
1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.
3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.