Overview

Secondary myelofibrosiss most frequently harbor alterations in JAK2, TET2, CALR, ASXL1, and EZH2 [2].

Most Commonly Altered Genes in Secondary Myelofibrosis

JAK2 V617F, JAK2 Mutation, JAK2 Exon 14 Mutation, CALR Mutation, and CALR L367fs are the most common alterations in secondary myelofibrosis [2].

Top Alterations in Secondary Myelofibrosis

Significant Genes in Secondary Myelofibrosis

AFF1 +

ELL +

KMT2A +

MECOM +

MLLT1 +

MLLT10 +

MLLT3 +

MLLT4 +

NRIP3 +

RPN1 +

Disease Details

Parent(s)
Myelofibrosis
Children
Polycythemia Vera, Post-Polycythemic Myelofibrosis Phase and Myelofibrosis Transformation in Essential Thrombocythemia

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.