Associated Genetic Biomarkers

Overview

NCI Definition: A rare, low grade invasive adenocarcinoma of the breast characterized by the presence of cells that secrete milk-like material. Morphologically, it usually appears as a circumscribed lesion, composed of cystic spaces, tubular structures, and solid areas. [1]

Secretory breast carcinomas most frequently harbor alterations in NTRK3 and ETV6 [2].

Most Commonly Altered Genes in Secretory Breast Carcinoma

NTRK3-ETV6 Fusion, NTRK3 Fusion, ETV6-NTRK3 Fusion, and ETV6 Fusion are the most common alterations in secretory breast carcinoma [2].

Top Alterations in Secretory Breast Carcinoma

Significant Genes in Secretory Breast Carcinoma

ETV6 +

NTRK1 +

NTRK2 +

NTRK3 +

Disease Details

Synonyms
Cystic Hypersecretory Carcinoma of the Breast, Cystic Hypersecretory Carcinoma of Breast, Juvenile Secretory Carcinoma of Breast, Juvenile Breast Carcinoma, Infiltrating Cystic Hypersecretory Duct Breast Carcinoma, Juvenile Secretory Breast Carcinoma, Secretory Carcinoma of the Breast, Juvenile Carcinoma of Breast, Cystic Hypersecretory Breast Carcinoma, Juvenile Carcinoma of the Breast, Juvenile Secretory Carcinoma of the Breast, Secretory Carcinoma, Invasive Cystic Hypersecretory Duct Breast Carcinoma, Secretory Carcinoma of Breast
Parent(s)
Breast Invasive Ductal Carcinoma
OncoTree Name
Juvenile Secretory Carcinoma of the Breast
OncoTree Code
JSCB

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.