Overview

NCI Definition: A radiosensitive malignant germ cell tumor found in the testis (especially undescended), and extragonadal sites (anterior mediastinum and pineal gland). It is characterized by the presence of uniform cells with clear or dense cytoplasm which contains glycogen, and by a large nucleus which contains one or more nucleoli. The neoplastic germ cells form aggregates separated by fibrous septa. The fibrous septa contain chronic inflammatory cells, mainly lymphocytes. [1]

Seminomas most frequently harbor alterations in KRAS, KIT, CDKN1B, NRAS, and CCND2 [2].

Most Commonly Altered Genes in Seminoma

KIT Mutation, KRAS Mutation, KRAS Exon 2 Mutation, KRAS Codon 12 Missense, and KIT Exon 17 Mutation are the most common alterations in seminoma [2].

Top Alterations in Seminoma

Disease Details

Synonyms
Seminoma, Pure, SEMINOMA, MALIGNANT
Parent(s)
Malignant Germ Cell Tumor
Children
Testicular Seminoma and Extragonadal Seminoma
OncoTree Name
Seminoma
OncoTree Code
SEM

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.