NCI Definition: A radiosensitive malignant germ cell tumor found in the testis (especially undescended), and extragonadal sites (anterior mediastinum and pineal gland). It is characterized by the presence of uniform cells with clear or dense cytoplasm which contains glycogen, and by a large nucleus which contains one or more nucleoli. The neoplastic germ cells form aggregates separated by fibrous septa. The fibrous septa contain chronic inflammatory cells, mainly lymphocytes. 
Seminomas most frequently harbor alterations in KRAS, KIT, CDKN1B, NRAS, and CCND2 .
KIT Mutation, KRAS Mutation, KRAS Exon 2 Mutation, KRAS Codon 12 Missense, and KIT Exon 17 Mutation are the most common alterations in seminoma .
There is 1 clinical trial for seminoma, of which 1 is open and 0 are completed or closed. Of the trial that contains seminoma as an inclusion criterion, 1 is phase 2 (1 open).
Carboplatin, gemcitabine, and veliparib are the most common interventions in seminoma clinical trials.
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.