Diseases /
Sinonasal Undifferentiated Carcinoma
Overview
NCI Definition: A rare, highly aggressive carcinoma that arises from the sinonasal tract. It is characterized by the presence of small to medium size malignant cells. The prognosis is poor. [1]
Sinonasal undifferentiated carcinomas most frequently harbor alterations in TP53, IDH2, CDKN2A, SETD2, and RB1 [2].
IDH2 Mutation, IDH2 Exon 4 Mutation, IDH2 Codon 172 Missense, TP53 Mutation, and IDH2 R172S are the most common alterations in sinonasal undifferentiated carcinoma [2].
Clinical Trials
Disease Details
References
1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.
3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.