Sinonasal Undifferentiated Carcinoma
NCI Definition: A rare, highly aggressive carcinoma that arises from the sinonasal tract. It is characterized by the presence of small to medium size malignant cells. The prognosis is poor. 
Sinonasal undifferentiated carcinomas most frequently harbor alterations in TP53, IDH2, CDKN2A, SETD2, and RB1 .
IDH2 Mutation, IDH2 Exon 4 Mutation, IDH2 Codon 172 Missense, TP53 Mutation, and IDH2 R172S are the most common alterations in sinonasal undifferentiated carcinoma .
There are 4 clinical trials for sinonasal undifferentiated carcinoma, of which 4 are open and 0 are completed or closed. Of the trials that contain sinonasal undifferentiated carcinoma as an inclusion criterion, 4 are phase 2 (4 open).
Cisplatin, docetaxel, and etoposide are the most common interventions in sinonasal undifferentiated carcinoma clinical trials.
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.