Overview

NCI Definition: A rare, highly aggressive carcinoma that arises from the sinonasal tract. It is characterized by the presence of small to medium size malignant cells. The prognosis is poor. [1]

Sinonasal undifferentiated carcinomas most frequently harbor alterations in IDH2 [2].

Most Commonly Altered Genes in Sinonasal Undifferentiated Carcinoma

IDH2 Mutation and IDH2 Codon 172 Missense are the most common alterations in sinonasal undifferentiated carcinoma [2].

Top Alterations in Sinonasal Undifferentiated Carcinoma

Disease Details

Synonyms
Sinonasal Anaplastic Carcinoma, Undifferentiated Sinonasal Cancer
Parent(s)
Undifferentiated Carcinoma
OncoTree Name
Sinonasal Undifferentiated Carcinoma
OncoTree Code
SNUC

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.