NCI Definition: A carcinoma that arises from the skin. Representative examples are basal cell carcinoma and squamous cell carcinoma. [1]

Skin carcinomas most frequently harbor alterations in TP53, NOTCH1, KMT2D, CDKN2A, and ROS1 [2].

Most Commonly Altered Genes in Skin Carcinoma

TP53 Mutation, TP53 Missense, TP53 c.217-c.1178 Missense, NOTCH1 Mutation, and KMT2D Mutation are the most common alterations in skin carcinoma [2].

Top Alterations in Skin Carcinoma

Disease Details

Non-Melanoma Cancer of Skin, nonmelanoma skin cancer, Skin Cancer, Non-Melanoma, Carcinoma of Skin, Carcinoma of the Skin, Non-Melanoma Cancer of the Skin, Non-Melanoma Skin Cancer
Malignant Skin Neoplasm
Adnexal Carcinoma, Pilomatrical Carcinoma, Scrotal Carcinoma, Keratinocyte Carcinoma, Merkel Cell Carcinoma, Trabecular Adenocarcinoma, Eyelid Carcinoma, and Adenoid Cystic Skin Carcinoma


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.