Overview

NCI Definition: A carcinoma that arises from the skin. Representative examples are basal cell carcinoma and squamous cell carcinoma. [1]

Skin carcinomas most frequently harbor alterations in TP53, NOTCH1, KMT2D, ROS1, and CDKN2A [2].

Most Commonly Altered Genes in Skin Carcinoma

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, NOTCH1 Mutation, and KMT2D Mutation are the most common alterations in skin carcinoma [2].

Top Alterations in Skin Carcinoma

Significant Genes in Skin Carcinoma

MLH1 +

MLH3 +

MSH2 +

MSH3 +

MSH6 +

PMS1 +

PMS2 +

Disease Details

Synonyms
Carcinoma of Skin, Non-Melanoma Cancer of the Skin, Non-Melanoma Cancer of Skin, Skin Cancer, Non-Melanoma, Non-Melanoma Skin Cancer, Carcinoma of the Skin, nonmelanoma skin cancer
Parent(s)
Malignant Skin Neoplasm
Children
Scrotal Carcinoma, Adnexal Carcinoma, Trabecular Adenocarcinoma, Basal Cell Carcinoma, Eyelid Carcinoma, Adenoid Cystic Skin Carcinoma, Pilomatrical Carcinoma, Skin Squamous Cell Carcinoma, and Merkel Cell Carcinoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.