Overview

NCI Definition: A neuroendocrine carcinoma composed of small malignant cells which are often said to resemble "oat cells" under the microscope. Small cell carcinoma most often affects the lungs. Clinically, this is often a rapidly growing cancer that spreads to distant sites early. [1]

Disease Details

Synonyms
High-Grade Neuroendocrine Carcinoma Small Cell Type, Small Cell NEC, Neuroendocrine Carcinoma Small Cell Type, Neuroendocrine carcinoma, c/w small cell carcinoma, Metastatic poorly differentiated neuroendocrine small cell carcinoma, Small cell car. (extrapulmonary), Poorly differentiated neuroendocrine small cell carcinoma, Small cell carcinoma (extrapulmonary), Metastatic small cell carcinoma, Oat Cell Cancer, Oat Cell Carcinoma, Small Cell Cancer, Small Cell Neuroendocrine Carcinoma
Parent(s)
Neuroendocrine Carcinoma
Children
Nasal Cavity and Paranasal Sinus Small Cell Neuroendocrine Carcinoma, Thymic Small Cell Carcinoma, Colorectal Small Cell Carcinoma, Small Intestinal Small Cell Carcinoma, Occult Small Cell Lung Carcinoma, Prostate Small Cell Carcinoma, Bartholin Gland Small Cell Carcinoma, Ovarian Small Cell Carcinoma, Salivary Gland Small Cell Carcinoma, Laryngeal Small Cell Carcinoma, Small Cell Lung Carcinoma, Esophageal Small Cell Neuroendocrine Carcinoma, Pancreatic Small Cell Neuroendocrine Carcinoma, Ampulla of Vater Small Cell Neuroendocrine Carcinoma, Ureter Small Cell Carcinoma, Gallbladder Small Cell Neuroendocrine Carcinoma, Vaginal Small Cell Neuroendocrine Carcinoma, Bladder Small Cell Neuroendocrine Carcinoma, Nasal Cavity and Paranasal Sinus Small Cell Carcinoma, Breast Small Cell Neuroendocrine Carcinoma, Endometrial Small Cell Carcinoma, Gastric Small Cell Neuroendocrine Carcinoma, Extrahepatic Bile Duct Small Cell Carcinoma, Cervical Small Cell Carcinoma, Small Cell Carcinoma of Unknown Primary, and Kidney Small Cell Carcinoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.