Overview

NCI Definition: A neuroendocrine carcinoma composed of small malignant cells which are often said to resemble "oat cells" under the microscope. Small cell carcinoma most often affects the lungs. Clinically, this is often a rapidly growing cancer that spreads to distant sites early. [1]

Small cell carcinomas most frequently harbor alterations in TP53, RB1, KMT2D, CREBBP, and PTEN [2].

Most Commonly Altered Genes in Small Cell Carcinoma

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 c.142-c.212 Missense, TP53 c.1-c.137 Missense, and TP53 Missense are the most common alterations in small cell carcinoma [2].

Top Alterations in Small Cell Carcinoma

Disease Details

Synonyms
Small cell carcinoma (extrapulmonary), Oat Cell Cancer, Oat Cell Carcinoma, Small cell car. (extrapulmonary), Small Cell NEC, Small Cell Cancer, Small Cell Neuroendocrine Carcinoma
Parent(s)
Neuroendocrine Carcinoma
Children
Nasal Cavity and Paranasal Sinus Small Cell Carcinoma, Esophageal Small Cell Neuroendocrine Carcinoma, Thymic Small Cell Carcinoma, Prostate Small Cell Carcinoma, Small Cell Carcinoma of Unknown Primary Origin, Ovarian Small Cell Carcinoma, Bartholin Gland Small Cell Carcinoma, Bladder Small Cell Neuroendocrine Carcinoma, Occult Small Cell Lung Carcinoma, Ampulla of Vater Small Cell Neuroendocrine Carcinoma, Cervical Small Cell Carcinoma, Endometrial Small Cell Carcinoma, Colon Small Cell Neuroendocrine Carcinoma, Gastric Small Cell Neuroendocrine Carcinoma, Kidney Small Cell Carcinoma, Extrahepatic Bile Duct Small Cell Neuroendocrine Carcinoma, Small Cell Lung Carcinoma, Ureter Small Cell Carcinoma, Gallbladder Small Cell Neuroendocrine Carcinoma, Nasal Cavity and Paranasal Sinus Small Cell Neuroendocrine Carcinoma, Laryngeal Small Cell Carcinoma, and Salivary Gland Small Cell Carcinoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.