Overview

NCI Definition: A neuroendocrine carcinoma composed of small malignant cells which are often said to resemble "oat cells" under the microscope. Small cell carcinoma most often affects the lungs. Clinically, this is often a rapidly growing cancer that spreads to distant sites early. [1]

Small cell carcinomas most frequently harbor alterations in TP53, RB1, KMT2D, CREBBP, and PTEN [2].

Most Commonly Altered Genes in Small Cell Carcinoma

TP53 Mutation, TP53 Missense, TP53 c.217-c.1178 Missense, RB1 Mutation, and TP53 Exon 5 Mutation are the most common alterations in small cell carcinoma [2].

Top Alterations in Small Cell Carcinoma

Disease Details

Synonyms
Small Cell NEC, Neuroendocrine Carcinoma Small Cell Type, Metastatic poorly differentiated neuroendocrine small cell carcinoma, Small cell car. (extrapulmonary), Oat Cell Carcinoma, Metastatic small cell carcinoma, High-Grade Neuroendocrine Carcinoma Small Cell Type, Small Cell Neuroendocrine Carcinoma, Small cell carcinoma (extrapulmonary), Oat Cell Cancer, Small Cell Cancer, Neuroendocrine carcinoma, c/w small cell carcinoma, Poorly differentiated neuroendocrine small cell carcinoma
Parent(s)
Neuroendocrine Carcinoma
Children
Thymic Small Cell Carcinoma, Occult Small Cell Lung Carcinoma, Ovarian Small Cell Carcinoma, Esophageal Small Cell Neuroendocrine Carcinoma, Pancreatic Small Cell Neuroendocrine Carcinoma, Cervical Small Cell Carcinoma, Extrahepatic Bile Duct Small Cell Carcinoma, Nasal Cavity and Paranasal Sinus Small Cell Neuroendocrine Carcinoma, Endometrial Small Cell Carcinoma, Nasal Cavity and Paranasal Sinus Small Cell Carcinoma, Colorectal Small Cell Carcinoma, Gallbladder Small Cell Neuroendocrine Carcinoma, Breast Small Cell Neuroendocrine Carcinoma, Bartholin Gland Small Cell Carcinoma, Gastric Small Cell Neuroendocrine Carcinoma, Kidney Small Cell Carcinoma, Ampulla of Vater Small Cell Neuroendocrine Carcinoma, Ureter Small Cell Carcinoma, Salivary Gland Small Cell Carcinoma, Small Cell Carcinoma of Unknown Primary, Laryngeal Small Cell Carcinoma, Bladder Small Cell Neuroendocrine Carcinoma, Small Intestinal Small Cell Carcinoma, Prostate Small Cell Carcinoma, and Small Cell Lung Carcinoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.