Overview

NCI Definition: A non-Hodgkin lymphoma composed of monomorphic small, round B-lymphocytes in the lymph nodes. When the lymphoid process predominantly involves the bone marrow and the peripheral blood it is called chronic lymphocytic leukemia. (WHO, 2001) [1]

Small lymphocytic lymphomas most frequently harbor alterations in SF3B1, NOTCH1, KMT2D, CDKN2A, and TP53 [2].

Most Commonly Altered Genes in Small Lymphocytic Lymphoma

SF3B1 Mutation, NOTCH1 Mutation, NOTCH1 Frameshift, KMT2D Mutation, and TP53 Mutation are the most common alterations in small lymphocytic lymphoma [2].

Top Alterations in Small Lymphocytic Lymphoma

Significant Genes in Small Lymphocytic Lymphoma

ABL1 +

AFF1 +

BCR +

CBFB +

CCND1 +

DEK +

ELL +

FGFR3 +

FLT3 +

IGH +

KIT +

KMT2A +

MAF +

MECOM +

MLLT1 +

MLLT10 +

MLLT3 +

MLLT4 +

MYC +

MYH11 +

NUP214 +

PBX1 +

RPN1 +

RUNX1 +

RUNX1T1 +

TCF3 +

TP53 +

Disease Details

Parent(s)
Mature B-Cell Non-Hodgkin Lymphoma
OncoTree Name
Small Lymphocytic Lymphoma
OncoTree Code
SLL

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.