Associated Genetic Biomarkers


NCI Definition: A benign or malignant myomatous neoplasm arising from smooth muscle. [1]

Smooth muscle neoplasms most frequently harbor alterations in TP53, RB1, ATRX, MED12, and PTEN [2].

Most Commonly Altered Genes in Smooth Muscle Neoplasm

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, RB1 Loss, and ATRX Mutation are the most common alterations in smooth muscle neoplasm [2].

Top Alterations in Smooth Muscle Neoplasm

Disease Details

Tumor of the Smooth Muscle, Smooth Muscle Tumor, Neoplasm of the Smooth Muscle, Neoplasm of Smooth Muscle, Tumor of Smooth Muscle
Myomatous Neoplasm
Leiomyoma, Uterine Corpus Smooth Muscle Neoplasm, and Esophagogastric Smooth Muscle Neoplasm


1. National Cancer Institute. NCI Thesaurus Version 18.11d. [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.