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Solid Neoplasm

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Associated Genetic Biomarkers

Overview

NCI Definition: A benign or malignant neoplasm arising from tissues that do not include fluid areas. Representative examples include epithelial neoplasms (e.g. lung carcinoma, prostate carcinoma, breast carcinoma, colon carcinoma), and neoplasms arising from the soft tissues and bones (e.g. leiomyosarcoma, liposarcoma, chondrosarcoma, osteosarcoma). Neoplasms originating from the blood or bone marrow (leukemias and myeloproliferative disorders) are not considered solid tumors. [1]

Solid neoplasms most frequently harbor alterations in TP53, KRAS, PIK3CA, APC, and CDKN2A [2].

Most Commonly Altered Genes in Solid Neoplasm

TP53 Mutation, TP53 Missense, TP53 c.217-c.1178 Missense, KRAS Mutation, and KRAS Exon 2 Mutation are the most common alterations in solid neoplasm [2].

Top Alterations in Solid Neoplasm

Clinical Trials

View Clinical Trials for Solid Neoplasm

Significant Genes in Solid Neoplasm

ABL1 +

BCR +

BRAF +

MYC +

NF1 +

Disease Details

Synonyms
Solid Tumor, Solid tumor, NOS
Parent(s)
Neoplasm
Children
Retroperitoneal Neoplasm, Embryonal Neoplasm, Brain Meningioma, Nervous System Neoplasm, Connective and Soft Tissue Neoplasm, Peritoneal Neoplasm, Thyroid Gland Neoplasm, Cardiovascular Neoplasm, Urinary System Neoplasm, Metastatic Neoplasm, Myeloma, Germ Cell Tumor, Skull Neoplasm, Sensory System Neoplasm, Giant Cell Neoplasm, Breast Neoplasm, Central Nervous System Neoplasm, Head and Neck Neoplasm, Pre-malignant Neoplasm, Malignant Solid Tumor, Mixed Neoplasm, Endocrine Neoplasm, Cerebellopontine Angle Tumor, Respiratory System Neoplasm, Mesoblastic Nephroma, Digestive System Neoplasm, Trophoblastic Neoplasm, and Neuroepithelial, Perineurial, and Schwann Cell Neoplasm

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.