Overview

NCI Definition: A benign or malignant neoplasm arising from tissues that do not include fluid areas. Representative examples include epithelial neoplasms (e.g. lung carcinoma, prostate carcinoma, breast carcinoma, colon carcinoma), and neoplasms arising from the soft tissues and bones (e.g. leiomyosarcoma, liposarcoma, chondrosarcoma, osteosarcoma). Neoplasms originating from the blood or bone marrow (leukemias and myeloproliferative disorders) are not considered solid tumors. [1]

Solid neoplasms most frequently harbor alterations in TP53, KRAS, PIK3CA, APC, and CDKN2A [2].

Most Commonly Altered Genes in Solid Neoplasm

TP53 Mutation, TP53 Missense, TP53 c.217-c.1178 Missense, KRAS Mutation, and KRAS Exon 2 Mutation are the most common alterations in solid neoplasm [2].

Top Alterations in Solid Neoplasm

Significant Genes in Solid Neoplasm

ABL1 +

BCR +

BRAF +

MYC +

NF1 +

Disease Details

Synonyms
Solid Tumor, Solid tumor, NOS
Parent(s)
Neoplasm
Children
Neuroepithelial, Perineurial, and Schwann Cell Neoplasm, Metastatic Neoplasm, Cerebellopontine Angle Tumor, Sensory System Neoplasm, Peritoneal Neoplasm, Retroperitoneal Neoplasm, Trophoblastic Neoplasm, Respiratory System Neoplasm, Cardiovascular Neoplasm, Digestive System Neoplasm, Pre-malignant Neoplasm, Endocrine Neoplasm, Urinary System Neoplasm, Breast Neoplasm, Giant Cell Neoplasm, Central Nervous System Neoplasm, Embryonal Neoplasm, Germ Cell Tumor, Head and Neck Neoplasm, Mesoblastic Nephroma, Brain Meningioma, Mixed Neoplasm, Thyroid Gland Neoplasm, Malignant Solid Tumor, Nervous System Neoplasm, Skull Neoplasm, Myeloma, and Connective and Soft Tissue Neoplasm

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.