Overview

NCI Definition: A benign or malignant neoplasm arising from tissues that do not include fluid areas. Representative examples include epithelial neoplasms (e.g. lung carcinoma, prostate carcinoma, breast carcinoma, colon carcinoma), and neoplasms arising from the soft tissues and bones (e.g. leiomyosarcoma, liposarcoma, chondrosarcoma, osteosarcoma). Neoplasms originating from the blood or bone marrow (leukemias and myeloproliferative disorders) are not considered solid tumors. [1]

Solid neoplasms most frequently harbor alterations in TP53, KRAS, PIK3CA, APC, and CDKN2A [2].

Most Commonly Altered Genes in Solid Neoplasm

TP53 Mutation, TP53 Missense, TP53 c.217-c.1178 Missense, KRAS Mutation, and PIK3CA Mutation are the most common alterations in solid neoplasm [2].

Top Alterations in Solid Neoplasm

Significant Genes in Solid Neoplasm

ABL1 +

BCR +

BRAF +

MYC +

NF1 +

Disease Details

Synonyms
Solid tumor, NOS, Solid Tumor
Parent(s)
Neoplasm
Children
Pre-malignant Neoplasm, Cerebellopontine Angle Tumor, Connective and Soft Tissue Neoplasm, Salivary Gland Neoplasm, Cardiovascular Neoplasm, Metastatic Neoplasm, Respiratory System Neoplasm, Brain Meningioma, Trophoblastic Neoplasm, Peritoneal Neoplasm, Embryonal Neoplasm, Refractory Malignant Neoplasm, Digestive System Neoplasm, Head and Neck Neoplasm, Thyroid Gland Neoplasm, Malignant Solid Tumor, Breast Neoplasm, Nervous System Neoplasm, Sensory System Neoplasm, Mesoblastic Nephroma, Myeloma, Endocrine Neoplasm, Retroperitoneal Neoplasm, Germ Cell Tumor, Neuroepithelial, Perineurial, and Schwann Cell Neoplasm, Central Nervous System Neoplasm, Urinary System Neoplasm, Central Nervous System Primitive Neuroectodermal Neoplasm, Mixed Neoplasm, Giant Cell Neoplasm, and Skull Neoplasm

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.