Overview

NCI Definition: A malignant mesenchymal neoplasm composed of spindle-shaped cells. This is a morphologic term which can be applied to a wide range of sarcomas. [1]

Spindle cell sarcomas most frequently harbor alterations in MDM2, CDK4, TERT, PDGFRA, and KIT [2].

MDM2 Amplification, CDK4 Amplification, PDGFRA Amplification, KIT Amplification, and TERT Amplification are the most common alterations in spindle cell sarcoma [2].

Significant Genes in Spindle Cell Sarcoma

Disease Details

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.