NCI Definition: A squamous cell carcinoma arising from the penis. It occurs chiefly in the squamous epithelium of the glans, coronal sulcus, and foreskin. Etiologic factors include phimosis, lichen sclerosus, smoking, ultraviolet irradiation, history of warts or condylomas, and lack of circumcision. Human papilloma virus is present in a subset of penile squamous cell carcinomas. Patients may present with an exophytic or flat ulcerative mass in the glans or a large primary tumor with inguinal nodal and skin metastases. Morphologic variants include the basaloid carcinoma, warty (condylomatous) carcinoma, verrucous carcinoma, and sarcomatoid (spindle cell) carcinoma. (WHO, 2004) [1]

Significant Genes in Squamous Cell Carcinoma of the Penis


MLH1 +

MLH3 +

MSH2 +

MSH3 +

MSH6 +

PMS1 +

PMS2 +


Disease Details

Epidermoid Carcinoma of the Penis, Penis squamous cell carcinoma (SCC), Penile squamous car.(epidermoid), Epidermoid Cell Carcinoma of Penis, Epidermoid Carcinoma of Penis, Penile Epidermoid Cell Carcinoma, Penile Epidermoid Carcinoma, Penile Squamous Cell Carcinoma, Penile squamous carcinoma (epidermoid), Epidermoid Cell Carcinoma of the Penis, Squamous Cell Carcinoma of Penis
Squamous Cell Carcinoma
Sarcomatoid Carcinoma of the Penis, Warty Penile Squamous Cell Carcinoma, Mixed Squamous Cell Carcinoma of the Penis, Verrucous Carcinoma of the Penis, Basaloid Carcinoma of the Penis, and Papillary Carcinoma of the Penis
OncoTree Name
Penile Squamous Cell Carcinoma
OncoTree Code


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.