NCI Definition: A squamous cell carcinoma arising from the penis. It occurs chiefly in the squamous epithelium of the glans, coronal sulcus, and foreskin. Etiologic factors include phimosis, lichen sclerosus, smoking, ultraviolet irradiation, history of warts or condylomas, and lack of circumcision. Human papilloma virus is present in a subset of penile squamous cell carcinomas. Patients may present with an exophytic or flat ulcerative mass in the glans or a large primary tumor with inguinal nodal and skin metastases. Morphologic variants include the basaloid carcinoma, warty (condylomatous) carcinoma, verrucous carcinoma, and sarcomatoid (spindle cell) carcinoma. (WHO, 2004) [1]

Squamous cell carcinoma of the peniss most frequently harbor alterations in TP53, KMT2D, PIK3CA, KMT2C, and FAT1 [2].

Most Commonly Altered Genes in Squamous Cell Carcinoma of the Penis

TP53 Mutation, KMT2D Mutation, KMT2C Mutation, CDKN2A Mutation, and PIK3CA Mutation are the most common alterations in squamous cell carcinoma of the penis [2].

Top Alterations in Squamous Cell Carcinoma of the Penis

Significant Genes in Squamous Cell Carcinoma of the Penis

CD274 +


Disease Details

Epidermoid Carcinoma of the Penis, Epidermoid Cell Carcinoma of Penis, Squamous Cell Carcinoma of Penis, Epidermoid Carcinoma of Penis, Penile Epidermoid Cell Carcinoma, Epidermoid Cell Carcinoma of the Penis, Penile squamous carcinoma (epidermoid), Penile Epidermoid Carcinoma, Penis squamous cell carcinoma (SCC), Penile squamous car.(epidermoid), Penile Squamous Cell Carcinoma
Squamous Cell Carcinoma
Mixed Squamous Cell Carcinoma of the Penis, Basaloid Carcinoma of the Penis, Verrucous Carcinoma of the Penis, Papillary Carcinoma of the Penis, Warty Penile Squamous Cell Carcinoma, and Sarcomatoid Carcinoma of the Penis
OncoTree Name
Penile Squamous Cell Carcinoma
OncoTree Code


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.