NCI Definition: A squamous cell carcinoma which has metastasized to another anatomic site and the original site of growth has not been identified. [1]

Squamous cell carcinoma of unknown primarys most frequently harbor alterations in TP53, CDKN2A, KMT2D, PIK3CA, and NOTCH1 [2].

Most Commonly Altered Genes in Squamous Cell Carcinoma of Unknown Primary

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, KMT2D Mutation, and PIK3CA Mutation are the most common alterations in squamous cell carcinoma of unknown primary [2].

Top Alterations in Squamous Cell Carcinoma of Unknown Primary

Disease Details

Squamous Cell Cancer of Unknown Primary Origin, Epidermoid Carcinoma of Unknown Primary Origin, Unknown primary squamous cell carcinoma (SCC), Squamous Cell Carcinoma of Unknown Primary Origin
Squamous Cell Carcinoma
OncoTree Name
Squamous Cell Carcinoma, NOS
OncoTree Code


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.