Associated Genetic Biomarkers


NCI Definition: A cytotoxic primary cutaneous T-cell lymphoma. Recent studies suggest there are at least two groups of subcutaneous panniculitis-like T-cell lymphomas, each with distinct histologic features, immunophenotypic profile, and prognosis. One group has an alpha/beta, CD8 positive phenotype, involves only subcutaneous tissues, and usually has an indolent clinical course. The second group has a gamma/delta phenotype, is CD8 negative, often co-expresses CD56, is not confined to the subcutaneous tissues, and usually has a poor prognosis. In the recent WHO-EORTC classification, the term subcutaneous panniculitis-like T-cell lymphoma is reserved for cases with an alpha/beta, CD8 positive phenotype. Cases with a gamma/delta phenotype are included in the group of cutaneous gamma/delta T-cell lymphomas. [1]

Significant Genes in Subcutaneous Panniculitis-Like T-Cell Lymphoma




CARD11 +

CD79A +

CD79B +



Disease Details

Subcutaneous Panniculitis-Like T-Cell Lymphoma, Alpha/Beta Type, Subcutaneous Panniculitis-Like T-Cell Lymphoma (Alpha/Beta Type), SPTCL
Primary Cutaneous T-Cell Non-Hodgkin Lymphoma
OncoTree Name
Subcutaneous Panniculitis-Like T-Cell Lymphoma
OncoTree Code


1. National Cancer Institute. NCI Thesaurus Version 18.11d. [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.