Overview

T-cell and NK-cell neoplasms most frequently harbor alterations in TET2, DNMT3A, TP53, NOTCH1, and CDKN2A [2].

Most Commonly Altered Genes in T-Cell and NK-Cell Neoplasm

TET2 Mutation, TET2fs, DNMT3A Mutation, TET2 Nonsense, and RHOA Mutation are the most common alterations in T-cell and NK-cell neoplasm [2].

Top Alterations in T-Cell and NK-Cell Neoplasm

Significant Genes in T-Cell and NK-Cell Neoplasm

ABL1 +

AFF1 +

BCR +

FLT3 +

IKZF1 +

KIT +

KMT2A +

MECOM +

MLF1 +

NPM1 +

PBX1 +

RPN1 +

TCF3 +

Disease Details

Parent(s)
Lymphocytic Neoplasm
Children
Mature T-Cell and NK-Cell Neoplasm and T-Cell Lymphoblastic Leukemia/Lymphoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.