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T-Cell/Histiocyte-Rich Large B-Cell Lymphoma
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Associated Genetic Biomarkers
Overview
NCI Definition: A large B-cell lymphoma characterized by the presence of a limited number of scattered neoplastic large B-lymphocytes which are admixed with numerous non-neoplastic T-lymphocytes and frequently histiocytes. [1]
T-cell/histiocyte-rich large B-cell lymphomas most frequently harbor alterations in TET2, KMT2D, CHEK2, and STAT3 [2].
TET2 Y1766*, TET2 W954*, TET2 Q1627*, TET2 Nonsense, and TET2 Mutation are the most common alterations in T-cell/histiocyte-rich large B-cell lymphoma [2].
Significant Genes in T-Cell/Histiocyte-Rich Large B-Cell Lymphoma
Disease Details
References
1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.
3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.