Overview

NCI Definition: A large B-cell lymphoma characterized by the presence of a limited number of scattered neoplastic large B-lymphocytes which are admixed with numerous non-neoplastic T-lymphocytes and frequently histiocytes. [1]

Significant Genes in T-Cell/Histiocyte-Rich Large B-Cell Lymphoma

AFF1 +

ALK +

BCL2 +

BCL6 +

ELL +

IRF4 +

KMT2A +

MLLT1 +

MLLT10 +

MLLT3 +

MLLT4 +

MYC +

Disease Details

Synonyms
THRLBCL, T-Cell Rich/Histiocyte-Rich Large B-Cell Lymphoma, T-Cell/Histiocyte Rich Lymphoma
Parent(s)
Diffuse Large B-Cell Lymphoma
OncoTree Name
T-Cell/Histiocyte-Rich Large B-Cell Lymphoma
OncoTree Code
THRLBCL

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.