Associated Genetic Biomarkers

Overview

NCI Definition: A T-cell peripheral neoplasm characterized by a persistent (>6 months) increase in the number of peripheral blood large granular lymphocytes, without a clearly identified cause. (WHO, 2001) [1]

T-cell large granular lymphocyte leukemias most frequently harbor alterations in STAT3, TET2, KMT2A, WT1, and TNFAIP3 [2].

Most Commonly Altered Genes in T-Cell Large Granular Lymphocyte Leukemia

STAT3 Mutation, STAT3 Exon 21 Mutation, TET2 Mutation, STAT3 Y640F, and TET2 Nonsense are the most common alterations in T-cell large granular lymphocyte leukemia [2].

Top Alterations in T-Cell Large Granular Lymphocyte Leukemia

Disease Details

Synonyms
Large Granular Lymphocytic Leukemia, T Gamma Lymphoproliferative Disorder, LEUKEMIA, LARGE GRANULAR LYMPHOCYTIC, MALIGNANT, T-LGL leukemia, Bone marrow leukemia T cell large granular (T-LGL), LGLL, Large Granular Lymphocytosis, T-cell large gran. lymph. leuk., Large Cell Granular Lymphoid Leukemia, T-Gamma Lymphoproliferative Disorder, Tgamma Large Granular Lymphocyte Leukemia, Large Cell Granular Lymphogenous Leukemia, T-Cell Large Granular Lymphocytic Leukemia
Parent(s)
Mature T-Cell and NK-Cell Neoplasm
OncoTree Name
T-Cell Large Granular Lymphocytic Leukemia
OncoTree Code
TLGL

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.