Diseases /
T-Cell Lymphoblastic Leukemia/Lymphoma
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Associated Genetic Biomarkers
Overview
NCI Definition: A neoplasm of lymphoblasts committed to the T-cell lineage, typically composed of small to medium-sized blast cells. When the neoplasm involves predominantly the bone marrow and the peripheral blood, it is called T acute lymphoblastic leukemia. When it involves nodal or extranodal sites it is called T lymphoblastic lymphoma. (WHO, 2001) [1]
T-cell lymphoblastic leukemia/lymphomas most frequently harbor alterations in NOTCH1, CDKN2A, CDKN2B, PHF6, and DNMT3A [2].
NOTCH1 Mutation, NOTCH1 Missense, NOTCH1 Exon 26 Mutation, CDKN2A Loss, and CDKN2B Loss are the most common alterations in T-cell lymphoblastic leukemia/lymphoma [2].
Clinical Trials
Significant Genes in T-Cell Lymphoblastic Leukemia/Lymphoma
Disease Details
References
1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.
3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.