Overview

NCI Definition: A neoplasm of lymphoblasts committed to the T-cell lineage, typically composed of small to medium-sized blast cells. When the neoplasm involves predominantly the bone marrow and the peripheral blood, it is called T acute lymphoblastic leukemia. When it involves nodal or extranodal sites it is called T lymphoblastic lymphoma. (WHO, 2001) [1]

Significant Genes in T-Cell Lymphoblastic Leukemia/Lymphoma

ABL1 +

AFF1 +

BCR +

DEK +

ELL +

FLT3 +

KMT2A +

MECOM +

MLF1 +

MLLT1 +

MLLT10 +

MLLT3 +

MLLT4 +

NPM1 +

NRIP3 +

NUP214 +

PBX1 +

RPN1 +

TCF3 +

TP53 +

Disease Details

Synonyms
Precursor T Lymphoblastic Leukemia/Lymphoma, Precursor T Lymphoblastic Lymphoma/Leukemia, T-Lymphoblastic Leukemia/Lymphoma, Bone marrow leukemia-lymphoma T-cell (NOS), T Lymphoblastic Leukemia/Lymphoma, T-lymphoblastic leukemia-lymphoma (T-ALL), Precursor T-Lymphoblastic Lymphoma/Leukemia, PEDIATRIC T-lymphoblastic leukemia-lymphoma (T-ALL)
Parent(s)
T-Cell and NK-Cell Neoplasm
Children
Mediastinal T Lymphoblastic Lymphoma, Childhood T-Cell Lymphoblastic Leukemia/Lymphoma, T-Cell Acute Lymphoblastic Leukemia, T-Cell Lymphoblastic Lymphoma, and Refractory T-Cell Lymphoblastic Leukemia/Lymphoma
OncoTree Name
T-Lymphoblastic Leukemia/Lymphoma
OncoTree Code
TLL

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.