Overview

T-cell non-hodgkin lymphomas most frequently harbor alterations in TET2, DNMT3A, RHOA, TP53, and KMT2D [2].

Most Commonly Altered Genes in T-Cell Non-Hodgkin Lymphoma

TET2 Mutation, TET2fs, RHOA Mutation, TET2 Nonsense, and RHOA G17V are the most common alterations in T-cell non-hodgkin lymphoma [2].

Top Alterations in T-Cell Non-Hodgkin Lymphoma

Significant Genes in T-Cell Non-Hodgkin Lymphoma

ABL1 +

AFF1 +

ASXL1 +

BCR +

DEK +

ELL +

FLT3 +

KMT2A +

MECOM +

MLF1 +

MLLT1 +

MLLT10 +

MLLT3 +

MLLT4 +

NPM1 +

NUP214 +

RPN1 +

RUNX1 +

TP53 +

Disease Details

Synonyms
Lymph node lymphoma T-cell (NOS)
Parent(s)
Non-Hodgkin Lymphoma
Children
T-Cell Lymphoblastic Lymphoma and Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.