NCI Definition: A non-seminomatous germ cell tumor characterized by the presence of various tissues which correspond to the different germinal layers (endoderm, mesoderm, and ectoderm). It occurs in the testis, ovary, and extragonadal sites including central nervous system, mediastinum, lung, and stomach. According to the level of differentiation of the tissues which comprise the tumor, teratomas are classified as mature or immature. Mature teratomas are composed of well differentiated, adult-type tissues. Immature teratomas are composed of immature, fetal-type tissues. Testicular teratomas in children follow a benign clinical course. Mature ovarian teratomas without a fetal-type component have an excellent outcome. The prognosis of immature ovarian teratomas is related to the grade and stage of the tumor. [1]

Teratomas most frequently harbor alterations in RAD52, PIK3C2G, KRAS, H3F3C, and ETV6 [2].

Most Commonly Altered Genes in Teratoma

RAD52 Amplification, PIK3C2G Amplification, KRAS Amplification, H3F3C Amplification, and ETV6 Amplification are the most common alterations in teratoma [2].

Top Alterations in Teratoma

Disease Details

Germ Cell Tumor
Teratoma with Malignant Transformation, Ovarian Teratoma, Immature Teratoma, Mediastinal Teratoma, Central Nervous System Teratoma, Adult Teratoma, Cystic Teratoma, Fallopian Tube Teratoma, Mature Teratoma, Testicular Teratoma, Gastric Teratoma, and Childhood Teratoma
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1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.