NCI Definition: A non-seminomatous germ cell tumor characterized by the presence of various tissues which correspond to the different germinal layers (endoderm, mesoderm, and ectoderm). It occurs in the testis, ovary, and extragonadal sites including central nervous system, mediastinum, lung, and stomach. According to the level of differentiation of the tissues which comprise the tumor, teratomas are classified as mature or immature. Mature teratomas are composed of well differentiated, adult-type tissues. Immature teratomas are composed of immature, fetal-type tissues. Testicular teratomas in children follow a benign clinical course. Mature ovarian teratomas without a fetal-type component have an excellent outcome. The prognosis of immature ovarian teratomas is related to the grade and stage of the tumor. [1]

Teratomas most frequently harbor alterations in TP53, PIK3CA, KMT2D, TET1, and PTEN [2].

Most Commonly Altered Genes in Teratoma

TP53 Mutation, PIK3CA Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, and TP53 Exon 5 Mutation are the most common alterations in teratoma [2].

Top Alterations in Teratoma

Disease Details

Nongerminomatous Germ Cell Tumor
Adult Teratoma, Malignant Teratoma, Ovarian Teratoma, Gastric Teratoma, Teratoma with Malignant Transformation, Testicular Teratoma, Central Nervous System Teratoma, Mediastinal Teratoma, Cystic Teratoma, Immature Teratoma, Childhood Teratoma, Fallopian Tube Teratoma, and Mature Teratoma
OncoTree Name
OncoTree Code


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.