Overview

NCI Definition: A malignant germ cell neoplasm arising from the testis. It is composed of primitive epithelial cells arranged in solid, papillary, and glandular configurations. Most patients present with a testicular mass, which may be associated with pain. More than half of the patients have metastatic disease at diagnosis. The form of treatment following radical orchiectomy is stage dependent. [1]

Testicular embryonal carcinomas most frequently harbor alterations in ETV6, CDKN1B, CCND2, RAD52, and KDM5A [2].

Most Commonly Altered Genes in Testicular Embryonal Carcinoma

CDKN1B Amplification, CCND2 Amplification, ETV6 Amplification, RAD52 Amplification, and KDM5A Amplification are the most common alterations in testicular embryonal carcinoma [2].

Top Alterations in Testicular Embryonal Carcinoma

Disease Details

Synonyms
Embryonal Carcinoma of Testis, Embryonal Carcinoma of the Testis
Parent(s)
Testicular Pure Germ Cell Tumor
Children
Childhood Testicular Embryonal Carcinoma and Stage 0 Testicular Embryonal Carcinoma
OncoTree Name
Embryonal Carcinoma
OncoTree Code
EMBCA

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.