NCI Definition: A germ cell tumor arising from the testis. Representative examples include teratoma, seminoma, embryonal carcinoma, and yolk sac tumor. [1]

Testicular germ cell tumors most frequently harbor alterations in KRAS, CDKN1B, CCND2, ETV6, and RAD52 [2].

Most Commonly Altered Genes in Testicular Germ Cell Tumor

CDKN1B Amplification, CCND2 Amplification, ETV6 Amplification, RAD52 Amplification, and KRAS Amplification are the most common alterations in testicular germ cell tumor [2].

Top Alterations in Testicular Germ Cell Tumor

Disease Details

TGCT, Testicular Germ Cell Neoplasm, Germ Cell Neoplasm of the Testis, Testicular Germ Cell Neoplasms, Germ Cell Neoplasm of Testis, Germ Cell Tumor of Testis, Germ Cell Tumor of the Testis
Malignant Testicular Neoplasm
Testicular Pure Germ Cell Tumor, Childhood Testicular Germ Cell Tumor, Malignant Testicular Germ Cell Tumor, and Testicular Non-Seminomatous Germ Cell Tumor


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.