Overview

NCI Definition: A myelodysplastic syndrome caused by chemotherapy and/or radiotherapy. [1]

Significant Genes in Therapy-Related Myelodysplastic Syndrome

ABL1 +

AFF1 +

ASXL1 +

BCR +

CBFB +

DEK +

DNMT3A +

ELL +

FGFR3 +

FLT3 +

IGH +

KIT +

KMT2A +

MAF +

MAFB +

MECOM +

MLLT1 +

MLLT10 +

MLLT3 +

MLLT4 +

MYH11 +

NUP214 +

PBX1 +

PHF6 +

RPN1 +

RUNX1 +

RUNX1T1 +

TCF3 +

TET2 +

TP53 +

WHSC1 +

Disease Details

Synonyms
t-MDS, Therapy-Related MDS, Therapy Related Myelodysplastic Syndrome
Parent(s)
Therapy-Related Myeloid Neoplasm
OncoTree Name
Therapy-Related Myelodysplastic Syndrome
OncoTree Code
TMDS

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.