Overview

NCI Definition: Acute myeloid leukemias, myelodysplastic syndromes, and myelodysplastic/myeloproliferative neoplasms arising as a result of the mutagenic effect of chemotherapy agents and/or radiation that are used for the treatment of neoplastic or non-neoplastic disorders. [1]

Significant Genes in Therapy-Related Myeloid Neoplasm

ABL1 +

AFF1 +

BCR +

KMT2A +

MECOM +

MLF1 +

NPM1 +

RPN1 +

Disease Details

Synonyms
Acute Myeloid Leukaemias and Myelodysplastic Syndromes, Therapy-Related, Therapy-Related Acute Myeloid Leukemia and Myelodysplastic Syndrome, Therapy-Related AML and MDS
Parent(s)
Therapy-Related Malignant Neoplasm
Children
Therapy-Related Acute Myeloid Leukemia, Therapy-Related Myelodysplastic/Myeloproliferative Neoplasm, and Therapy-Related Myelodysplastic Syndrome
OncoTree Name
Therapy-Related Myeloid Neoplasms
OncoTree Code
TMN

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.