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Thymic Carcinoid Tumor

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Associated Genetic Biomarkers

Overview

NCI Definition: A primary thymic neuroendocrine tumor, often associated with Cushing syndrome. Two morphologic subtypes are recognized: typical and atypical carcinoid tumors. Atypical carcinoid tumors have a more aggressive clinical course. [1]

Thymic carcinoid tumors most frequently harbor alterations in MEN1, SMARCA4, PLCG2, HRAS, and ANKRD11 [2].

Most Commonly Altered Genes in Thymic Carcinoid Tumor

SMARCA4 Mutation, MEN1 Mutation, HRAS Mutation, HRAS Missense, and HRAS Codon 61 Missense are the most common alterations in thymic carcinoid tumor [2].

Top Alterations in Thymic Carcinoid Tumor

Clinical Trials

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Disease Details

Synonyms
Thymic Neuroendocrine Tumor, Thymus Carcinoid, Carcinoid Tumor of the Thymus, Thymus Carcinoid Tumor, Carcinoid Tumor of Thymus, Thymic Carcinoid
Parent(s)
Thymic Neuroendocrine Neoplasm
Children
Thymic Typical Carcinoid Tumor and Thymic Atypical Carcinoid Tumor
OncoTree Name
Thymic Neuroendocrine Tumor
OncoTree Code
TNET

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.