Overview

NCI Definition: A neoplasm arising from the epithelial cells of the thymus. Although thymomas are usually encapsulated tumors, they may invade the capsule and infiltrate the surrounding tissues or even metastasize to distant anatomic sites. The following morphologic subtypes are currently recognized: type A, type B, type AB, metaplastic, micronodular, microscopic, and sclerosing thymoma. Thymomas type B are further subdivided into types B1, B2, and B3. Thymoma type B3 usually has the most aggressive clinical course. [1]

Significant Genes in Thymoma

ERBB2 +

MLH1 +

MLH3 +

MSH2 +

MSH3 +

MSH6 +

NTRK1 +

PMS1 +

PMS2 +

Disease Details

Synonyms
THYMOMA, UNDETERMINED, Thymus thymoma (NOS)
Parent(s)
Thymic Epithelial Neoplasm
Children
Thymoma Type A, Thymoma Type B, Malignant Thymoma, Invasive Thymoma, Encapsulated Thymoma, Dendritic Cell Thymoma, and Thymoma Type AB
OncoTree Name
Thymoma
OncoTree Code
THYM

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.