NCI Definition: A neoplasm arising from the epithelial cells of the thymus. Although thymomas are usually encapsulated tumors, they may invade the capsule and infiltrate the surrounding tissues or even metastasize to distant anatomic sites. The following morphologic subtypes are currently recognized: type A, type B, type AB, metaplastic, micronodular, microscopic, and sclerosing thymoma. Thymomas type B are further subdivided into types B1, B2, and B3. Thymoma type B3 usually has the most aggressive clinical course. 
Thymomas most frequently harbor alterations in TP53, DNMT3A, WRN, SETD2, and PDGFRA .
TP53 c.217-c.1178 Missense, TP53 Mutation, TP53 Missense, TP53 Exon 5 Mutation, and WRN Mutation are the most common alterations in thymoma .
There are 9 clinical trials for thymoma, of which 9 are open and 0 are completed or closed. Of the trials that contain thymoma as an inclusion criterion, 4 are phase 1 (4 open), 4 are phase 2 (4 open), and 1 is no phase specified (1 open).
Vmd-928, xmab20717, and allogeneic hematopoietic stem cell transplantation are the most common interventions in thymoma clinical trials.
Significant Genes in Thymoma
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.