Overview

NCI Definition: A neuroendocrine carcinoma arising from the C-cells of the thyroid gland. It is closely associated with multiple endocrine neoplasia syndromes. Approximately 10% to 20% of medullary thyroid carcinomas are familial. Patients usually present with a thyroid nodule that is painless and firm. In the majority of cases nodal involvement is present at diagnosis. Surgery is the preferred treatment for both primary lesions and recurrences. This carcinoma is generally not very sensitive to radiation and almost unresponsive to chemotherapy. [1]

Significant Genes in Thyroid Gland Medullary Carcinoma

ACBD5 +

AFAP1L2 +

AXL +

CCDC6 +

CEP43 +

ERC1 +

GOLGA5 +

HOOK3 +

KIAA1217 +

KIF5B +

MET +

NCOA4 +

PPFIBP2 +

PRKAR1A +

RET +

RUFY1 +

TFG +

TRIM27 +

Disease Details

Synonyms
Medullary Carcinoma, Parafollicular Cell Carcinoma, Medullary Thyroid Gland Carcinoma, Thyroid Gland Neuroendocrine Carcinoma, CARCINOMA, C-CELL, MALIGNANT, Medullary Thyroid Cancer, C Cell Carcinoma, Medullary Carcinoma of Thyroid Gland, Medullary Carcinoma of the Thyroid Gland, MTC, Thyroid Medullary Carcinoma, Medullary Carcinoma of the Thyroid, Medullary Thyroid Carcinoma, Medullary Carcinoma of Thyroid
Parent(s)
Thyroid Gland Carcinoma
OncoTree Name
Medullary Thyroid Cancer
OncoTree Code
THME

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.