Overview

NCI Definition: A follicular carcinoma of the thyroid gland, characterized by the presence of large cells with eosinophilic granular cytoplasm and pleomorphic nuclei with prominent, eosinophilic nucleoli. The nuclear features that characterize the papillary carcinomas of the thyroid gland are absent. [1]

Thyroid gland oncocytic follicular carcinomas most frequently harbor alterations in TP53, PTEN, NF1, TBX3, and KMT2D [2].

Most Commonly Altered Genes in Thyroid Gland Oncocytic Follicular Carcinoma

TP53 Mutation, PTEN Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, and TP53 Exon 8 Mutation are the most common alterations in thyroid gland oncocytic follicular carcinoma [2].

Top Alterations in Thyroid Gland Oncocytic Follicular Carcinoma

Disease Details

Synonyms
Hurthle Cell Carcinoma of Thyroid Gland, Oncocytic Carcinoma of Thyroid, Hurthle Cell Thyroid Gland Carcinoma, Hurthle Cell Carcinoma of the Thyroid Gland, Hurthle Cell Carcinoma of the Thyroid, Thyroid follicular oncocytic carcinoma, Oncocytic Carcinoma of the Thyroid, Thyroid Oncocytic Carcinoma, Hurthle Cell Carcinoma of Thyroid, Thyroid Hurthle Cell Carcinoma, Thyroid Gland Hurthle Cell Carcinoma
Parent(s)
Thyroid Gland Follicular Carcinoma
OncoTree Name
Hurthle Cell Thyroid Cancer
OncoTree Code
THHC

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.