Tongue Squamous Cell Carcinoma
Associated Genetic Biomarkers
NCI Definition: A squamous cell carcinoma that arises from the tongue. It usually presents as a painful ulcerated or nodular lesion. The size of the tumor and the status of the lymph nodes are the most important factors that determine prognosis. 
There are 2 clinical trials for tongue squamous cell carcinoma, of which 2 are open and 0 are completed or closed. Of the trials that contain tongue squamous cell carcinoma as an inclusion criterion, 1 is phase 3 (1 open) and 1 is no phase specified (1 open).
CDKN2A and HPV are the most frequent gene inclusion criteria for tongue squamous cell carcinoma clinical trials .
Cisplatin, durvalumab, and intensity-modulated radiation therapy are the most common interventions in tongue squamous cell carcinoma clinical trials.
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.