Tonsillar Squamous Cell Carcinoma
Associated Genetic Biomarkers
NCI Definition: A squamous cell carcinoma that arises from the mucosal lining of the tonsil and tends to metastasize early to the lymph nodes. It predominantly affects middle aged and elderly patients who have a history of alcohol and tobacco use. Patients may present with tonsillar swelling, sore throat, pain radiating to the ipsilateral ear, or a neck mass. 
There are 5 clinical trials for tonsillar squamous cell carcinoma, of which 5 are open and 0 are completed or closed. Of the trials that contain tonsillar squamous cell carcinoma as an inclusion criterion, 4 are phase 2 (4 open) and 1 is phase 3 (1 open).
CDKN2A and HPV are the most frequent gene inclusion criteria for tonsillar squamous cell carcinoma clinical trials .
Intensity-modulated radiation therapy, cisplatin, and isa101b are the most common interventions in tonsillar squamous cell carcinoma clinical trials.
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.