Trophoblastic neoplasms most frequently harbor alterations in TP53, KMT2D, RAD52, KDM5A, and ETV6 [2].

Most Commonly Altered Genes in Trophoblastic Neoplasm

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, RAD52 Amplification, and KMT2D Mutation are the most common alterations in trophoblastic neoplasm [2].

Top Alterations in Trophoblastic Neoplasm

Disease Details

Solid Neoplasm
Epithelioid Trophoblastic Tumor, Gestational Trophoblastic Tumor, Choriocarcinoma, Testicular Trophoblastic Tumor, and Hydatidiform Mole


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.