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Unclassified Renal Cell Carcinoma

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Associated Genetic Biomarkers

Overview

NCI Definition: A renal cell carcinoma characterized by morphologic features that do not fit easily into one of the other well-defined categories of renal cell carcinoma. Examples of such features include mixtures of morphologic patterns, mucin production, and sarcomatoid morphology. [1]

Unclassified renal cell carcinomas most frequently harbor alterations in NF2, SETD2, TP53, BAP1, and CDKN2B [2].

Most Commonly Altered Genes in Unclassified Renal Cell Carcinoma

TP53 Mutation, NF2 Mutation, CDKN2B Loss, TP53 c.217-c.1178 Missense, and TP53 Missense are the most common alterations in unclassified renal cell carcinoma [2].

Top Alterations in Unclassified Renal Cell Carcinoma

Clinical Trials

View Clinical Trials for Unclassified Renal Cell Carcinoma

Significant Genes in Unclassified Renal Cell Carcinoma

SDHB +

SMARCB1 +

TFE3 +

TSC1 +

Disease Details

Synonyms
Unclassified Renal Cell Cancer
Parent(s)
Non-Clear Cell Renal Cell Carcinoma
OncoTree Name
Unclassified Renal Cell Carcinoma
OncoTree Code
URCC

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.