Overview

NCI Definition: A renal cell carcinoma characterized by morphologic features that do not fit easily into one of the other well-defined categories of renal cell carcinoma. Examples of such features include mixtures of morphologic patterns, mucin production, and sarcomatoid morphology. [1]

Unclassified renal cell carcinomas most frequently harbor alterations in NF2, SETD2, TP53, CDKN2B, and BAP1 [2].

Most Commonly Altered Genes in Unclassified Renal Cell Carcinoma

NF2 Mutation, SETD2 Mutation, TP53 Mutation, CDKN2B Loss, and BAP1 Mutation are the most common alterations in unclassified renal cell carcinoma [2].

Top Alterations in Unclassified Renal Cell Carcinoma

Significant Genes in Unclassified Renal Cell Carcinoma

SDHB +

SMARCB1 +

TFE3 +

TSC1 +

Disease Details

Synonyms
Unclassified Renal Cell Cancer
Parent(s)
Non-Clear Cell Renal Cell Carcinoma
OncoTree Name
Unclassified Renal Cell Carcinoma
OncoTree Code
URCC

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.