Overview

NCI Definition: A carcinoma that arises from the stomach and is characterized by the absence of microscopic features of glandular or squamous differentiation. [1]

Undifferentiated gastric carcinomas most frequently harbor alterations in TP53, ZNF708, SMARCA4, RPTOR, and ROS1 [2].

Most Commonly Altered Genes in Undifferentiated Gastric Carcinoma

ZNF708 Loss, TP53fs, TP53 c.217-c.1178 Missense, TP53 R282W, and TP53 Mutation are the most common alterations in undifferentiated gastric carcinoma [2].

Top Alterations in Undifferentiated Gastric Carcinoma

Significant Genes in Undifferentiated Gastric Carcinoma

CD274 +

Disease Details

Synonyms
Undifferentiated Carcinoma of Stomach, Anaplastic Carcinoma of Stomach, Anaplastic Carcinoma of the Stomach, Undifferentiated Gastric (Stomach) Cancer, Gastric Undifferentiated Carcinoma, Anaplastic Gastric Carcinoma, Undifferentiated Carcinoma of the Stomach, Undifferentiated Stomach Adenocarcinoma
Parent(s)
Undifferentiated Carcinoma
OncoTree Name
Undifferentiated Stomach Adenocarcinoma
OncoTree Code
USTAD

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.