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Undifferentiated High Grade Pleomorphic Sarcoma of Bone

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Overview

NCI Definition: A rare, high-grade pleomorphic malignant neoplasm arising from the bone. It usually presents with pain which may or may not be associated with swelling in the affected area. It is characterized by the presence of spindle-shaped cells, polygonal or epithelioid cells, multinucleated giant cells, and inflammatory cells. The neoplastic cells exhibit nuclear pleomorphism and high mitotic activity. It metastasizes frequently, most often in the lungs. [1]

Clinical Trials

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Disease Details

Synonyms
Undifferentiated High-Grade Pleomorphic Sarcoma, Undifferentiated High Grade Pleomorphic Sarcoma, Malignant Fibrous Histiocytoma of Bone, Malignant Fibrous Histiocytoma of the Bone, Malignant Bone Fibrous Histiocytoma
Parent(s)
Undifferentiated Pleomorphic Sarcoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.