Undifferentiated High Grade Pleomorphic Sarcoma of Bone
NCI Definition: A rare, high-grade pleomorphic malignant neoplasm arising from the bone. It usually presents with pain which may or may not be associated with swelling in the affected area. It is characterized by the presence of spindle-shaped cells, polygonal or epithelioid cells, multinucleated giant cells, and inflammatory cells. The neoplastic cells exhibit nuclear pleomorphism and high mitotic activity. It metastasizes frequently, most often in the lungs. 
There are 2 clinical trials for undifferentiated high grade pleomorphic sarcoma of bone, of which 2 are open and 0 are completed or closed. Of the trials that contain undifferentiated high grade pleomorphic sarcoma of bone as an inclusion criterion, 1 is phase 1 (1 open) and 1 is phase 2 (1 open).
Bo-112, eribulin, and nivolumab are the most common interventions in undifferentiated high grade pleomorphic sarcoma of bone clinical trials.
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.