Overview

NCI Definition: An undifferentiated soft tissue sarcoma characterized by the presence of a pleomorphic malignant cellular infiltrate. It is also known as malignant fibrous histiocytoma. [1]

Significant Genes in Undifferentiated Pleomorphic Sarcoma

AKT1 +

AKT2 +

AKT3 +

CRKL +

MTOR +

MYCN +

PDGFRA +

PIK3CA +

PIK3CG +

PIK3R1 +

PIK3R2 +

PTEN +

RICTOR +

RPTOR +

TSC1 +

TSC2 +

Disease Details

Synonyms
Storiform-Pleomorphic Fibrous Histiocytoma, Unclassified Pleomorphic Sarcoma (Formerly "Malignant Fibrous Histiocytoma"), Malignant Fibroxanthoma, Undifferentiated Pleomorphic Soft Tissue Sarcoma, Malignant Fibrous Histiocytoma, Fibroxanthosarcoma, Storiform-Pleomorphic Malignant Fibrous Histiocytoma, Unclassified Pleomorphic Sarcoma (Formerly "MFH"), Malignant Fibrous Histiocytoma of Soft Tissue and Bone, MFH, malignant fibrous cytoma, HISTIOCYTOMA, FIBROUS, MALIGNANT, Unclassified Pleomorphic Sarcoma, UPS, Malignant Fibrous Histiocytoma of the Soft Tissue and Bone, Storiform-Pleomorphic MFH
Parent(s)
Undifferentiated/Unclassified Sarcoma
Children
Undifferentiated High Grade Pleomorphic Sarcoma of Bone, Undifferentiated Pleomorphic Sarcoma with Osteoclast-Like Giant Cells, Cutaneous Undifferentiated Pleomorphic Sarcoma, Undifferentiated Pleomorphic Sarcoma, Inflammatory Variant, and Malignant Fibroxanthoma
OncoTree Name
Undifferentiated Pleomorphic Sarcoma/Malignant Fibrous Histiocytoma/High-Grade Spindle Cell Sarcoma
OncoTree Code
MFH

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.