NCI Definition: An adenocarcinoma that arises from the male or female urethra. [1]

Urethral adenocarcinomas most frequently harbor alterations in TP53, KRAS, TERT, SMARCB1, and FBXW7 [2].

Most Commonly Altered Genes in Urethral Adenocarcinoma

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, KRAS Mutation, and KRAS Exon 2 Mutation are the most common alterations in urethral adenocarcinoma [2].

Top Alterations in Urethral Adenocarcinoma

Disease Details

Adenocarcinoma of Urethra, Adenocarcinoma of the Urethra, Urethra Adenocarcinoma
Urethral Carcinoma
Urethral Clear Cell Adenocarcinoma
OncoTree Name
Urethral Adenocarcinoma
OncoTree Code


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.